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Some prefer a few hours of driving each morning, then enjoying their destination the rest of the day. Others want to spend an entire day driving and checking out one single location. It also depends on what you want to see and where you want to go.
You can do a combination of driving and other transportation methods. If you aren’t going to drive in that direction on your road trip, a quick train ride will get you there quickly and easily. Then, you can take the train back and continue the road trip.